Biology is undergoing a revolution, and we are at the forefront. In this program, we seek to understand the living world as an interacting set of complex systems, crafted by natural selection to carry out defined tasks. The program is designed to meet the interdisciplinary training challenges of modern biology. Our students receive training and research experience in the tools of applied mathematics, computation, data analytics, and experimental methods in “-omics”, molecular, cellular and developmental biology.
What Sets Us Apart?
- Faculty members from 22 departments, including biology, computing, engineering, mathematics, medicine, physics and statistics
- After the rigorous first year “gateway”, the PhD program allows the flexibility to transfer into 10 departmental PhD programs or remain in the interdisciplinary PhD program
- Close and continual interaction with the UCI Center for Complex Biological Systems, Center for Cancer Systems Biology, Center for Multiscale Cell Fate Research, Laboratory for Fluorescence Dynamics and many other campus resources
Normative Time to Degree
Students interested in the MCSB Program apply to the Office of Graduate Studies (OGS). Applicants must specify that they wish to pursue the M.S. or Ph.D. Upon completion of the M.S., students who may wish to pursue a Ph.D. may request to be evaluated together with the pool of prospective Ph.D. candidates for admission to the Ph.D. program.
Applicants are expected to hold a Bachelor’s degree in one of the Science, Technology, Engineering, and Mathematics (STEM) fields. Applicants are evaluated on the basis of their prior academic record and their potential for creative research and teaching, as demonstrated in submitted application materials (official university transcripts, letters of recommendation, GRE scores, and statement of purpose).
The MCSB curriculum is designed to teach students at the beginning of their graduate careers the necessary mathematical, computational, and biological knowledge for successful research at the interface between these disciplines. The needs of students with a variety of backgrounds can be met provided that they have had mathematical training comparable to a standard one-year university-level calculus course and a lower-division university course in elementary differential equations and linear algebra. Exceptional students not meeting these prerequisites may be admitted to the program on the condition that they fulfill these requirements during the first fall quarter of their graduate study or the summer preceding, and pass with a grade of B or better.
The MCSB Executive Committee and Director act as the admissions committee. Following an initial screening of applications, the Executive Committee usually invites potential trainees for an interview at UCI. The Director makes final offers of admissions to applicants, based on the recommendations of the interviewing faculty and the Executive Committee.
Applications are made through the Office of Graduate Studies using the Online Application. Once logged in to the online application, the applicant will see that the graduate programs are organized by school/department. Please select: "Interdisciplinary Programs" from the the "School/Department" drop-down menu. Then select "Mathematical, Computational and Systems Biology Biology Ph.D." or "Mathematical, Computational and Systems Biology M.S." from the "Major/Degree" menu.
The MCSB Admissions Committee will be able to consider your application for Fall admission when all of the following items have been received. Please send only official copies and no photocopied documents.
- Online Application: Click here for details on how to apply online.
- Application Fee: Application Fee - Your application cannot be reviewed until UCI has received your non-refundable application fee ($105 for U.S. Citizens and lawful U.S. Permanent Residents, and $125 for all other applicants).
- The university also grants full application fee waivers to certain U.S. citizens and permanent residents with strong financial need (For more information and instructions, go to:http://www.grad.uci.edu/admissions/applying-to-uci/fee-waivers.php)
- Official Transcripts: Only ONE COPY of the Official Transcript is now needed. Send transcripts from all post-secondary institutions attended directly from the Registrar 's Office at your undergraduate institution.
- Also include a Certificate of Graduation indicating your Bachelor Degree award.
- Three (3) Letters of Recommendation: Reference forms for use by the recommender are included in the online application. For the Academic Degree Program, indicate MCSB.
- Graduate Record Exam (GRE) General Test Scores: All applicants are required to submit an official GRE record, which can be obtained through the Educational Testing Service (ETS). For score reporting, the institution code for UCI is 4859.
- TOEFL/IELTS Scores: Only applicants whose primary language is not English are required to demonstrate proficiency in English for admission consideration. However, this requirement may be waived for applicants who have received an advanced degree from an accredited U.S. college or university. Proficiency in English may be demonstrated by passing one of two standardized, internationally administered tests: TOEFL (the Test of English as a Foreign Language); or IELTS (International English Language Testing System). For score reporting, the institution code is 4859.
- Application Progress Review: Once you submit your application, check here to see whether your GRE scores, English proficiency test scores (if required), or letters of recommendation (if submitted electronically) have been received by the Office of Graduate Studies.
Once submitted, your application materials will not, under any circumstances, be returned to you or forwarded to another entity on your behalf.
Click here for additional information on applying to UCI and answers to frequently asked questions.
Tuition & Fees
Graduate/Credential Student Fees 2018-19
|Fall 2018||Winter 2019||Spring 2019||Annual|
|Student Services Fee||376.00||376.00||376.00||1,128.00|
|Assoc. Grad Students Fee||9.00||9.00||9.00||27.00|
|Student Center Fee||137.88||137.88||137.87||413.63|
|Bren Events Center Fee||23.00||23.00||23.00||69.00|
|Recreation Center Fee||88.00||88.00||88.00||264.00|
|eTech Fee *||60.00||60.00||60.00||180.00|
|Document Fee †||80.00||0.00||0.00||80.00|
|Student Health Insurance||1,348.00||1,347.00||1,347.00||4,042.00|
|Total California Resident||$5,795.88||$5,794.88||$5,794.87||$17,385.63|
|Nonresident Supplemental Tuition||5,034.00||5,034.00||5,034.00||15,102.00|
Posted 10 August 2018 at http://reg.uci.edu/fees/2018-2019/graduate.html.
The tuition, fees, and charges posted to your billing statement or account are estimates based on currently approved amounts. These figures may not be final. Actual tuition, fees, and charges are subject to change by the Regents of the University of California and could be affected by increases or reductions in State funding, or other developments. Accordingly, final approved levels (and thus your final balance due) may differ from the amounts shown.
* The non-refundable eTech Fee is required of all students and is used to support the maintenance and improvement of existing education technology, and new services and capabilities. The eTech fee is listed separately as the charged amount varies based on the amount of undergraduate units the student is enrolled in and is assessed later in the term than the other fees listed. The fee is $4 per unit of undergraduate lecture course, up to a maximum amount of $60 (or 15 units) per quarter. It will be assessed after the third week of instruction. The $60 eTech Fee included on this chart reflects the maximum possible fee.
† The Document Fee provides lifetime access to official transcripts and academic verifications without a fee for in-person pickup or delivery by USPS. In addition, there is no fee for mailing the initial diploma. Effective Fall 2018, new undergraduate, professional, and graduate students are assessed the one-time document fee. Eligible students are able to use financial aid to cover the Document Fee.
Mathematical modeling of cell mechanics; How forces are used by cells for cell-cell communication, actin-based crawling, internal transport and cytoskeleton dynamics; Nonlinear partial differential equations, stochastic simulation and Bayesian statistics.
Microbial enzymes, theoretical ecology, and biogeochemistry
Transcriptional regulation in normal and diseased epithelia
Interface of structural molecular biology and physical chemistry
Drosophila development, TGF-beta signal transduction, cell signaling
Cell fate decisions in skin cancer, skin and hair follicle development, and stem cells.
Artificial Intelligence: Automated Reasoning / Machine Learning / Data Mining / Large-Scale Data Analysis: Information Access & Management / Computational Biology / Bioinformatics / Systems Biology
Use of molecular biology, biochemistry, genetics, cell biology and math/computation to study fundamental questions of cell signaling and regulation
Evolutionary and comparative physiology
Molecular embryology, molecular biology, developmental biology, functional genomics, endocrinology, pharmacology, high-throughput screening
The relationship between mechanical stresses on cells and molecular signaling, or cellular mechanotransduction. Investigation of the role of the glycocalix in the transduction of fluid shear stress at the wall of blood vessels, and is constructing an instrument to study the scale of mechanical induction of vascular inflammation.
Single molecule dynamics, bioinformatics, functional genomics, surface plasmon resonance
Systems Biology of Stem Cells and Human Developmental Disorders
Theoretical analysis and practical application of Adaptive Finite Element Methods (AFEMs)
Growth factor signaling and functional genomics in Xenopus and zebrafish, stem cell research and diabetes, Bioinformatics and functional genomics, Veterbrate embryology and growth factor signaling
Systems biology of cell differentiation.
NMR spectroscopy, DNA-binding proteins, membrane proteins, cancer
Nanomaterial Synthesis & Characterization, Nanocircuit Behaviors, Single Molecule Circuits
Effect of exercise on gene and protein expression of key inflammatory and growth mediators in peripheral blood mononuclear cells in health children
Role of the regulatory proteins Ovo in germ cell and epidermal differentiation
Biological physics, Langmuir monolayers, Foams
Evolution of genetic novelty: copy number variation, gene duplication, sex chromosome evolution and the evolution of gene expression
Mathematical Biology; developing generic modules for biochemical reactions in little b and to study signal transduction pathways associated with EGF receptors.
Biosphere-atmosphere interactions, plant stress emissions in an evolving world, links between ecology and climate
Artificial Intelligence: Automated Reasoning / Machine Learning / Data MiningBio-Medical Informatics / Computational Biology
Evolutionary genetics, host-parasite interactions, development of mathematical, computational and conceptual models to study complex phenotypes
population genetics, molecular evolution, genome evolution
Design of new fluorescence instruments, protein dynamics, hydration of proteins, and I.R. spectroscopy of biological substances
Applying multiscale computational modeling and tissue engineering to stem cell-derived cardiomyocytes (heart muscle cells), cardiac morphogenesis (development of structure), and cardiac function.
Biophysics of molecular motors and intracellular transport
Partial Differential Equations and Applied (Functional) Analysis
Targeted drug delivery, clinical cancer detection, nanotechnology, molecular engineering, computational simulations
Large-Scale Data Analysis: Information Access & Management / Databases / Information Infrastructure / Bio-Medical Informatics / Computational Biology
Mechanisms of pre-mRNA splicing and the function of splicing enhancers in exon definition, Regulation of pre-mRNA splicing and human genetic diseases, The coupling of transcription and pre-mRNA splicing
Biological mass spectrometry/proteomics, ubiquitin-proteasome degradation pathways, protein complexes, posttranslational modifications, protein-protein interaction
Blood vessel development, angiogenesis in cancer, bioengineering of blood vessels and tissues
MEMS, cell-cell interactions, tissue engineering, global health
Artificial Intelligence: Automated Reasoning / Machine Learning / Data Mining
Molecular biology of insect vectors of disease, genetics of vector competence, malaria, dengue fever
Control of the cell cycle through mechanisms involving ubiquitination
Cellular communication in single cell resolution in the context of normal tissue homeostasis and in breast cancer.
Bone biomechanics and structural analysis ; Effects of medications, aging, tumors, radiotherapy, and spaceflight on bone ; Cancer and radiotherapy ; Imaging using quantitative computed tomography
Cardiovascular engineering with emphasis on cardiac mechanics, cardiac imaging and cardiovascular devices
Quantitative Single-Cell Analysis of Receptor Dynamics and Chemotactic Response on a Chip
Mathematical biology: modeling of cancer initiation and progression, dynamics of DNA transcription and repair, modeling of learning and evolution of language
Systems biology of morphogenesis and pattern formation, proteoglycans, extracellular matrix, birth defects syndromes
Bacteriorhodopsin, spectroscopy, protein crystallography
Artificial Intelligence: Automated Reasoning / Machine Learning / Data Mining / Bio-Medical Informatics / Computational Biology / Protein Structure Prediction / Drug Discovery / Genetic Regulation
Metabolic engineering and Synthetic biology for production of chemicals from renewable resources.
Synthetic biology, chemical biology, and directed evolution.
MAP kinase mediated signal transduction; dimorphic regulation in yeast
Understanding how microenvironmental cues regulate cell behavior in order to better understand and treat diseases of the cardiovasculature
Quantitative and population genetics, genetic basis of quantitative variation for different phenotypes in different organisms, gene mapping and microarray analysis
Microstructured Materials, Multiphase Flows, Crystal Growth, Nanostructure Patterning, Metallic Alloys, Tumor Growth, Tissue Engineering
Leucke, Hartmut "Hudel"
Protein crystallography, structure function studies, membrane proteins, bacteriorhodopsin, annexi, G protein-coupled receptors (GPCR), structure-based drug design
Computational Biology, Protein Structure, Protein Function
Theoretical Chemistry, Chemical Physics
Microbiology, Environmental Genomics, Oceanography
Biomechanics, Locomotion, Sensory Biology
Artificial Intelligence: Automated Reasoning / Machine Learning / Data Mining / Bio-Medical Informatics / Computational Biology / Systems Biology / Scientific Inference Systems / Mathematical Methods
Roles of morphogens and transcription factors in early NSC fate control and boundary formation involving the cortex and specialized tissues at the midline
Applications of genomics, computation, and sequencing technologies to the analysis of transcriptional regulation in development. Emphasis on long-range protein-DNA interactions, ChIP-seq, RNA-seq, ChIA-PET, and comparative genomics
Theoretical studies of ultrafast dynamics and relaxation processes of large molecules, biological complexes, and semiconductors; Nonlinear ultrafast spectroscopy
Adaptive biomedical signal processing, control algorithms for biomedical devices, brain-machine interfaces, modeling and analysis of biological neural networks
Self-assembly of biological and biomimetic nanoscale materials based on amino acids and on nucleic acids using computational and theoretical methods
Computational Biology, Developmental and Cell Biology, Numerical Analsis, Interface Dynamics in Materials and Fluids, High-Performance Computing, Modeling and Simulation of Tissue Patterning, Systems Biology
Organic and Bioorganic Chemistry, Chemical Biology, Biomolecular Nanotechnology
Stem cells and stem cell niche, Regeneration of tissues and organs, Biological pattern formation, Self-organization, Skin and hair follicles, Adipose tissue, WNT and BMP signaling pathways
Molecular mobility in biological materials, vibrational coherences, ultrafast microscopy
Structural evolutionary genomics and evolution of the expression network
Dynamics of complex biochemical systems and regulation of immune responses
Biological physics, magnetic sense of animals, quantum biology of photosynthesis
Molecular genetics and biochemistry of retrotransposons and metabolic engineering in budding yeast
Zebrafish development, pattern formation, morphogenesis
Developing Bayesian methods and applying them to real-world problems; applying novel statistical methods to solve research questions in genetics, genomics, proteomics, and cancer studies
Physical and Biophysical Chemistry; NMR Spectroscopy; Chemistry of Aging; Nuclear Power; Radiochemistry
Sheu, Phillip C-Y
Database Systems, Object-Oriented Systems, Parallel Processing, Simulation, Interactive Multimedia Systems. Biomedical Database Management, Intranet/Internet Technologies
Biomechanics, Bacterial Signaling, Bacterial Pathogens, Biofilms
Experimental Biophysics, Condensed Matter Physics
Artificial Intelligence: Automated Reasoning / Machine Learning / Data MiningLarge-Scale Data Analysis: Information Access & Management / Databases / Information Infrastructure; Internet Technologies / Applications; Statistics
Applied mathematics, applied probablility, stochastic differential equations
Molecular biology of Hydra development
statistical inference using Bayesian methods, assessing the fit of statistical models, applications of statistics in the social and biological sciences, and statistics in sports.
Surface physics, sensors, high speed imaging, and fluid mechanics
Gene Expression and Pathogenesis in Chlamydia Trachomatis
Comparative genomics, Population Genetics, and statistical Genetics
Computational Chemistry, Biophysical Chemistry, Atmospheric Chemistry
Lasers, near infrared spectroscopy, non-invasive diagnostics, photomedicine, biomedical optics, photodynamic therapy
Biochemistry, Chemical Biology, Structural Biology, Microbiology
Biomedical laser applications, optical diffusion theory, photothermal and photomechanical phenomena
Wan, Frederic Y.M.
Applied Mathematics, Solid Mechanics, Resource Economics, Biomathematics
Protein-protein interaction network, Hippo signaling, Organ size control, Molecular mechanism of tumorigenesis
Drosophila development, regulation of nuclear position and migration, effects of proteoglycans in growth factor signaling, regulation of developmental gene expression.
Regulation of gene expression by LEF/TCF - beta-catenin complexes
Bioorganic chemistry, chemical biology, protein engineering, molecular biology and biochemistry
Whiteson , Katrine
Host-associated microbial communities, metabolomics, metagenomics, microbial ecology, phage, fermentation, polymicrobial infection, microbial interactions, human microbiome
Nano metrology to in-situ sensors that improve the throughput and/or yield in manufacturing lines to novel instruments for ultra fast sequencing of DNA and nanoscale metrology in biology
Mathematical and Computational Biology, Theoretical Biology, infectious diseases and the immune system, carcinogenesis & cancer treatment
Experimental and computational approaches to studying the regulation of gene expression, Drosophila development, and interpreting natural variation in regulatory sequences
Computational Biology, Bioinformatics, Genomics, Neural Computation, and Machine Learning
Analysis and Modeling of Reaction-Diffusion-Advection Fronts, Stochastic Partial Differential Equations, Asymptotics and Computations, Multiscale Analysis of Partial Differential Equations and Applications, Mathematical Modeling in Speech and Hearing Sciences.
Mechanism and regulation of chromosome structural changes required for the maintenance of genome integrity
Biological physics, Intracellular transport, Disordered systems
The Level Set Method, Moving Interface and Free Boundary, Image Processing and Computer Graphics, Time Reversal and Wave Propagation, Domain Decomposition
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