Graduate Division

Mathematical, Computational, and Systems Biology MS

Section 1

Overview

Biology is undergoing a revolution, and we are at the forefront. In this program, we seek to understand the living world as an interacting set of complex systems, crafted by natural selection to carry out defined tasks. The program is designed to meet the interdisciplinary training challenges of modern biology. Our students receive training and research experience in the tools of applied mathematics, computation, data analytics, and experimental methods in “-omics”, molecular, cellular and developmental biology.

What Sets Us Apart?

  • Faculty members from 22 departments, including biology, computing, engineering, mathematics, medicine, physics and statistics
  • After the rigorous first year “gateway”, the PhD program allows the flexibility to transfer into 10 departmental PhD programs or remain in the interdisciplinary PhD program
  • Close and continual interaction with the UCI Center for Complex Biological Systems, Center for Cancer Systems Biology, Center for Multiscale Cell Fate Research, Laboratory for Fluorescence Dynamics and many other campus resources

Quick Facts

Program Type

Academic Master's Program

Normative Time to Degree

2 years

Capstone Type

Research Thesis or Literature Thesis

Accordion Section

Admissions Requirements

Students interested in the MCSB Program apply to the Office of Graduate Studies (OGS). Applicants must specify that they wish to pursue the M.S. or Ph.D. Upon completion of the M.S., students who may wish to pursue a Ph.D. may request to be evaluated together with the pool of prospective Ph.D. candidates for admission to the Ph.D. program.

Applicants are expected to hold a Bachelor’s degree in one of the Science, Technology, Engineering, and Mathematics (STEM) fields. Applicants are evaluated on the basis of their prior academic record and their potential for creative research and teaching, as demonstrated in submitted application materials (official university transcripts, letters of recommendation, GRE scores, and statement of purpose).
 
Prerequisites:
The MCSB curriculum is designed to teach students at the beginning of their graduate careers the necessary mathematical, computational, and biological knowledge for successful research at the interface between these disciplines. The needs of students with a variety of backgrounds can be met provided that they have had mathematical training comparable to a standard one-year university-level calculus course and a lower-division university course in elementary differential equations and linear algebra. Exceptional students not meeting these prerequisites may be admitted to the program on the condition that they fulfill these requirements during the first fall quarter of their graduate study or the summer preceding, and pass with a grade of B or better.
 
Admissions Information:
The MCSB Executive Committee and Director act as the admissions committee. Following an initial screening of applications, the Executive Committee usually invites potential trainees for an interview at UCI. The Director makes final offers of admissions to applicants, based on the recommendations of the interviewing faculty and the Executive Committee.
 
Program Application:
Applications are made through the Office of Graduate Studies using the Online Application. Once logged in to the online application, the applicant will see that the graduate programs are organized by school/department. Please select: "Interdisciplinary Programs" from the the "School/Department" drop-down menu. Then select "Mathematical, Computational and Systems Biology Biology Ph.D." or "Mathematical, Computational and Systems Biology M.S."  from the "Major/Degree" menu.

The MCSB Admissions Committee will be able to consider your application for Fall admission when all of the following items have been received. Please send only official copies and no photocopied documents.

  • Online Application: Click here for details on how to apply online.
  • Application Fee: Application Fee - Your application cannot be reviewed until UCI has received your non-refundable application fee ($105 for U.S. Citizens and lawful U.S. Permanent Residents, and $125 for all other applicants).
  • Official Transcripts: Only ONE COPY of the Official Transcript is now needed. Send transcripts from all post-secondary institutions attended directly from the Registrar 's Office at your undergraduate institution.
    • Also include a Certificate of Graduation indicating your Bachelor Degree award.
  • Three (3) Letters of Recommendation: Reference forms for use by the recommender are included in the online application. For the Academic Degree Program, indicate MCSB.
  • Graduate Record Exam (GRE) General Test Scores: All applicants are required to submit an official GRE record, which can be obtained through the Educational Testing Service (ETS).  For score reporting, the institution code for UCI is 4859.
  • TOEFL/IELTS Scores: Only applicants whose primary language is not English are required to demonstrate proficiency in English for admission consideration. However, this requirement may be waived  for applicants who have received an advanced degree from an accredited U.S. college or university. Proficiency in English may be demonstrated by passing one of two standardized, internationally administered tests: TOEFL (the Test of English as a Foreign Language); or IELTS (International English Language Testing System).   For score reporting,  the institution code is 4859.
  • Application Progress Review: Once you submit your application, check here to see whether your GRE scores, English proficiency test scores (if required), or letters of recommendation (if submitted electronically) have been received by the Office of Graduate Studies.

Once submitted, your application materials will not, under any circumstances, be returned to you or forwarded to another entity on your behalf.


Click here for additional information on applying to UCI and answers to frequently asked questions.

Financial Support

We encourage you to learn more about the array of financial support resources, such as fellowship competitions open to incoming and current UCI students, and funding workshops and writing tutors available through the Graduate Resource CenterMaster’s students are typically self-supported but may be eligible for these resources.

For information on funding opportunities for international graduate students, read more here.

Click here to access the associated nomination and application deadlines for various fellowship opportunities.
Click here for a summary of funding eligibility for UCI graduate students who meet AB540 and/or DACA criteria.

Tuition & Fees

Graduate/Credential Student Fees 2018-19

  Fall 2018 Winter 2019 Spring 2019 Annual
Student Services Fee 376.00 376.00 376.00 1,128.00
Tuition 3,814.00 3,814.00 3,814.00 11,442.00
Assoc. Grad Students Fee 9.00 9.00 9.00 27.00
Student Center Fee 137.88 137.88 137.87 413.63
Bren Events Center Fee 23.00 23.00 23.00 69.00
Recreation Center Fee 88.00 88.00 88.00 264.00
eTech Fee * 60.00 60.00 60.00 180.00
Document Fee † 80.00 0.00 0.00 80.00
Student Health Insurance 1,348.00 1,347.00 1,347.00 4,042.00
Total California Resident $5,795.88 $5,794.88 $5,794.87 $17,385.63
Nonresident Supplemental Tuition 5,034.00 5,034.00 5,034.00 15,102.00
Total Nonresident $10,829.88 $10,828.88 $10,828.87 $32,487.63

Posted 10 August 2018 at http://reg.uci.edu/fees/2018-2019/graduate.html

The tuition, fees, and charges posted to your billing statement or account are estimates based on currently approved amounts. These figures may not be final. Actual tuition, fees, and charges are subject to change by the Regents of the University of California and could be affected by increases or reductions in State funding, or other developments. Accordingly, final approved levels (and thus your final balance due) may differ from the amounts shown.

The non-refundable eTech Fee is required of all students and is used to support the maintenance and improvement of existing education technology, and new services and capabilities. The eTech fee is listed separately as the charged amount varies based on the amount of undergraduate units the student is enrolled in and is assessed later in the term than the other fees listed. The fee is $4 per unit of undergraduate lecture course, up to a maximum amount of $60 (or 15 units) per quarter. It will be assessed after the third week of instruction. The $60 eTech Fee included on this chart reflects the maximum possible fee.

† The Document Fee provides lifetime access to official transcripts and academic verifications without a fee for in-person pickup or delivery by USPS. In addition, there is no fee for mailing the initial diploma. Effective Fall 2018, new undergraduate, professional, and graduate students are assessed the one-time document fee. Eligible students are able to use financial aid to cover the Document Fee.

Core Faculty

Allard, Jun     
Mathematical modeling of cell mechanics; How forces are used by cells for cell-cell communication, actin-based crawling, internal transport and cytoskeleton dynamics; Nonlinear partial differential equations, stochastic simulation and Bayesian statistics.


Allison, Steven     
Microbial enzymes, theoretical ecology, and biogeochemistry


Andersen, Bogi     
Transcriptional regulation in normal and diseased epithelia


Andricioaei, Ioan     
Interface of structural molecular biology and physical chemistry


Arora, Kavita     
Drosophila development, TGF-beta signal transduction, cell signaling


Atwood, Scott     
Cell fate decisions in skin cancer, skin and hair follicle development, and stem cells.


Baldi, Pierre 
Artificial Intelligence: Automated Reasoning / Machine Learning / Data Mining / Large-Scale Data Analysis: Information Access & Management / Computational Biology / Bioinformatics / Systems Biology


Bardwell, Lee     
Use of molecular biology, biochemistry, genetics, cell biology and math/computation to study fundamental questions of cell signaling and regulation


Bennett, Albert     
Evolutionary and comparative physiology


Blumberg, Bruce     
Molecular embryology, molecular biology, developmental biology, functional genomics, endocrinology, pharmacology, high-throughput screening


Botvinick, Elliot     
The relationship between mechanical stresses on cells and molecular signaling, or cellular mechanotransduction. Investigation of the role of the glycocalix in the transduction of fluid shear stress at the wall of blood vessels, and is constructing an instrument to study the scale of mechanical induction of vascular inflammation.


Brody, Jim     
Single molecule dynamics, bioinformatics, functional genomics, surface plasmon resonance


Calof, Anne     
Systems Biology of Stem Cells and Human Developmental Disorders


Chen, Long     
Theoretical analysis and practical application of Adaptive Finite Element Methods (AFEMs)


Cho, Ken     
Growth factor signaling and functional genomics in Xenopus and zebrafish, stem cell research and diabetes, Bioinformatics and functional genomics, Veterbrate embryology and growth factor signaling


Cinquin, Olivier 
Systems biology of cell differentiation.


Cocco, Melanie 
NMR spectroscopy, DNA-binding proteins, membrane proteins, cancer


Collins, Philip     
Nanomaterial Synthesis  & Characterization, Nanocircuit Behaviors, Single Molecule Circuits


Cooper, Dan     
Effect of exercise on gene and protein expression of key inflammatory and growth mediators in peripheral blood mononuclear cells in health children


Dai, Xing     
Role of the regulatory proteins Ovo in germ cell and epidermal differentiation


Dennin, Michael     
Biological physics, Langmuir monolayers, Foams


Emerson, J.J.     
Evolution of genetic novelty: copy number variation, gene duplication, sex chromosome evolution and the evolution of gene expression


Enciso, German     
Mathematical Biology; developing generic modules for biochemical reactions in little b and to study signal transduction pathways associated with EGF receptors.


Faiola, Celia 
Biosphere-atmosphere interactions, plant stress emissions in an evolving world, links between ecology and climate


Fowlkes, Charless     
Artificial Intelligence: Automated Reasoning / Machine Learning / Data MiningBio-Medical Informatics / Computational Biology


Frank, Steve     
Evolutionary genetics, host-parasite interactions, development of mathematical, computational and conceptual models to study complex phenotypes


Gaut, Brandon     
population genetics, molecular evolution, genome evolution


Gratton, Enrico     
Design of new fluorescence instruments, protein dynamics, hydration of proteins, and I.R. spectroscopy of biological substances


Grosberg, Anna     
Applying multiscale computational modeling and tissue engineering to stem cell-derived cardiomyocytes (heart muscle cells), cardiac morphogenesis (development of structure), and cardiac function.


Gross, Steve     
Biophysics of molecular motors and intracellular transport


Guidotti, Patrick 
Partial Differential Equations and Applied (Functional) Analysis


Haun, Jered     
Targeted drug delivery, clinical cancer detection, nanotechnology, molecular engineering, computational simulations


Hayes, Wayne     
Large-Scale Data Analysis: Information Access & Management / Databases / Information Infrastructure / Bio-Medical Informatics / Computational Biology


Hertel, Klemens     
Mechanisms of pre-mRNA splicing and the function of splicing enhancers  in exon definition, Regulation of pre-mRNA splicing and human genetic diseases, The coupling of transcription and pre-mRNA splicing


Huang, Lan     
Biological mass spectrometry/proteomics, ubiquitin-proteasome degradation pathways, protein complexes, posttranslational modifications, protein-protein interaction


Hughes, Christopher     
Blood vessel development, angiogenesis in cancer, bioengineering of blood vessels and tissues


Hui, Elliot     
MEMS, cell-cell interactions, tissue engineering, global health


Ihler, Alexander     
Artificial Intelligence: Automated Reasoning / Machine Learning / Data Mining


James, Anthony     
Molecular biology of insect vectors of disease, genetics of vector competence, malaria, dengue fever


Kaiser, Peter     
Control of the cell cycle through mechanisms involving ubiquitination


Kessenbrock, Kai     
Cellular communication in single cell resolution in the context of normal tissue homeostasis and in breast cancer.


Keyak, Joyce     
Bone biomechanics and structural analysis ; Effects of medications, aging, tumors, radiotherapy, and spaceflight on bone ; Cancer and radiotherapy ; Imaging using quantitative computed tomography


Kherardvar, Arash     
Cardiovascular engineering with emphasis on cardiac mechanics, cardiac imaging and cardiovascular devices


Khine, Michelle     
Quantitative Single-Cell Analysis of Receptor Dynamics and Chemotactic Response on a Chip


Komarova, Natalia     
Mathematical biology: modeling of cancer initiation and progression,  dynamics of DNA transcription and repair, modeling of learning and evolution of language


Lander, Arthur     
Systems biology of morphogenesis and pattern formation, proteoglycans, extracellular matrix, birth defects syndromes


Lanyi, Janos     
 Bacteriorhodopsin, spectroscopy, protein crystallography


Lathrop, Rick     
Artificial Intelligence: Automated Reasoning / Machine Learning / Data Mining / Bio-Medical Informatics / Computational Biology / Protein Structure Prediction / Drug Discovery / Genetic Regulation


Li, Han     
Metabolic engineering and Synthetic biology for production of chemicals from renewable resources.


Liu, Chang     
Synthetic biology, chemical biology, and directed evolution.


Liu, Haoping     
MAP kinase mediated signal transduction; dimorphic regulation in yeast


Liu, Wendy     
Understanding how microenvironmental cues regulate cell behavior in order to better understand and treat diseases of the cardiovasculature


Long, Anthony     
Quantitative and population genetics, genetic basis of quantitative variation for different phenotypes in different organisms, gene mapping and microarray analysis


Lowengrub, John     
Microstructured Materials, Multiphase Flows, Crystal Growth, Nanostructure Patterning, Metallic Alloys, Tumor Growth, Tissue Engineering


Leucke, Hartmut "Hudel" 
Protein crystallography, structure function studies, membrane proteins, bacteriorhodopsin, annexi, G protein-coupled receptors (GPCR), structure-based drug design


Luo, Ray     
Computational Biology, Protein Structure, Protein Function


Martens, Craig 
Theoretical Chemistry, Chemical Physics


Martiny, Adam     
Microbiology, Environmental Genomics, Oceanography


McHenry, Matthew
Biomechanics, Locomotion, Sensory Biology


Mjolsness, Eric     
Artificial Intelligence: Automated Reasoning / Machine Learning / Data Mining / Bio-Medical Informatics / Computational Biology / Systems Biology / Scientific Inference Systems / Mathematical Methods


Monuki, Edwin     
Roles of morphogens and transcription factors in early NSC fate control and boundary formation involving the cortex and specialized tissues at the midline


Mortazavi, Ali     
Applications of genomics, computation, and sequencing technologies to the analysis of transcriptional regulation in development. Emphasis on long-range protein-DNA interactions, ChIP-seq, RNA-seq, ChIA-PET, and comparative genomics


Mukamel, Shaul 
Theoretical studies of ultrafast dynamics and relaxation processes of large molecules, biological complexes, and semiconductors; Nonlinear ultrafast spectroscopy


Nenadic, Zoran     
Adaptive biomedical signal processing, control algorithms for biomedical devices, brain-machine interfaces, modeling and analysis of biological neural networks


Nguyen, Hung     
Self-assembly of biological and biomimetic nanoscale materials based on amino acids and on nucleic acids using computational and theoretical methods


Nie, Qing     
Computational Biology, Developmental and Cell Biology, Numerical Analsis, Interface Dynamics in Materials and Fluids, High-Performance Computing, Modeling and Simulation of Tissue Patterning, Systems Biology


Nowick, James  
Organic and Bioorganic Chemistry, Chemical Biology, Biomolecular Nanotechnology


Plikus, Maksim     
Stem cells and stem cell niche, Regeneration of tissues and organs, Biological pattern formation, Self-organization, Skin and hair follicles, Adipose tissue, WNT and BMP signaling pathways


Potma, Eric     
Molecular mobility in biological materials, vibrational coherences, ultrafast microscopy


Ranz, Jose     
Structural evolutionary genomics and evolution of the expression network


Read, Elizabeth     
Dynamics of complex biochemical systems and regulation of immune responses


Ritz, Thorsten     
Biological physics, magnetic sense of animals, quantum biology of photosynthesis


Sandmeyer, Suzanne     
Molecular genetics and biochemistry of retrotransposons and metabolic engineering in budding yeast


Schilling, Tom     
Zebrafish development, pattern formation, morphogenesis


Shahbaba, Babak     
Developing Bayesian methods and applying them to real-world problems; applying novel statistical methods to solve research questions in genetics, genomics, proteomics, and cancer studies


Shaka, A.J.     
Physical and Biophysical Chemistry; NMR Spectroscopy; Chemistry of Aging; Nuclear Power; Radiochemistry


Sheu, Phillip C-Y     
Database Systems, Object-Oriented Systems, Parallel Processing, Simulation, Interactive Multimedia Systems. Biomedical Database Management, Intranet/Internet Technologies


Siryaporn, Albert     
Biomechanics, Bacterial Signaling, Bacterial Pathogens, Biofilms


Siwy, Zuzanna     
Experimental Biophysics, Condensed Matter Physics


Smyth, Padhraic     
Artificial Intelligence: Automated Reasoning / Machine Learning / Data MiningLarge-Scale Data Analysis: Information Access & Management / Databases / Information Infrastructure; Internet Technologies / Applications; Statistics


Solna, Knut     
Applied mathematics, applied probablility, stochastic differential equations


Steele, Robert     
Molecular biology of Hydra development


Stern, Hal     
statistical inference using Bayesian methods, assessing the fit of statistical models, applications of statistics in the social and biological sciences, and statistics in sports.


Taborek, Peter     
Surface physics, sensors, high speed imaging, and fluid mechanics


Tan, Ming     
Gene Expression and Pathogenesis in Chlamydia Trachomatis


Thornton, Kevin     
Comparative genomics, Population Genetics, and statistical Genetics


Tobias, Douglas     
Computational Chemistry, Biophysical Chemistry, Atmospheric Chemistry


Tromberg, Bruce     
Lasers, near infrared spectroscopy, non-invasive diagnostics, photomedicine, biomedical optics, photodynamic therapy


Tsai, Sheryl     
Biochemistry, Chemical Biology, Structural Biology, Microbiology


Venugopalan, Vasan     
Biomedical laser applications, optical diffusion theory, photothermal and photomechanical phenomena


Wan, Frederic Y.M.     
Applied Mathematics, Solid Mechanics, Resource Economics, Biomathematics


Wang, Wenqi     
Protein-protein interaction network, Hippo signaling, Organ size control, Molecular mechanism of tumorigenesis


Warrior, Rahul     
Drosophila development, regulation of nuclear position and migration, effects of proteoglycans in growth factor signaling, regulation of developmental gene expression.  


Waterman, Marian     
Regulation of gene expression by LEF/TCF - beta-catenin complexes


Weiss, Gregory     
Bioorganic chemistry, chemical biology, protein engineering, molecular biology and biochemistry


Whiteson , Katrine     
Host-associated microbial communities, metabolomics, metagenomics, microbial ecology, phage, fermentation, polymicrobial infection, microbial interactions, human microbiome


Wickramasinghe, H. Kumar

Nano metrology to in-situ sensors that improve the throughput and/or yield in manufacturing lines to novel instruments for ultra fast sequencing of DNA and nanoscale metrology in biology


Wodarz, Dominik     
Mathematical and Computational Biology, Theoretical Biology, infectious diseases and the immune system, carcinogenesis & cancer treatment


Wunderlich, Zeba     
Experimental and computational approaches to studying the regulation of gene expression, Drosophila development, and interpreting natural variation in regulatory sequences


Xie, Xiaohui     
Computational Biology, Bioinformatics, Genomics, Neural Computation, and Machine Learning


Xin, Jack     
Analysis and Modeling of Reaction-Diffusion-Advection Fronts, Stochastic Partial Differential Equations, Asymptotics and Computations, Multiscale Analysis of Partial Differential Equations and Applications, Mathematical Modeling in Speech and Hearing Sciences.


Yokomori, Kyoko     
Mechanism and regulation of chromosome structural changes required for the maintenance of genome integrity


Yu, Clare     
Biological physics, Intracellular transport, Disordered systems


Zhao, Hong-kai     
The Level Set Method, Moving Interface and Free Boundary, Image Processing and Computer Graphics, Time Reversal and Wave Propagation, Domain Decomposition

Academic Data

academic data

Please click here for data accessible to a screen reader.

Students & Alumni

Coming soon.